PTPσ inhibitors promote hematopoietic stem cell regeneration

Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecule inhibitors of PTPσ that promote HSC regeneration...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Yurun, Roos, Martina, Himburg, Heather, Termini, Christina M., Quarmyne, Mamle, Li, Michelle, Zhao, Liman, Kan, Jenny, Fang, Tiancheng, Yan, Xiao, Pohl, Katherine, Diers, Emelyne, Jin Gim, Hyo, Damoiseaux, Robert, Whitelegge, Julian, McBride, William, Jung, Michael E., Chute, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694155/
https://ncbi.nlm.nih.gov/pubmed/31413255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11490-5
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