Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant transformation over time. Extrinsic regulation of HSC DNA repair is not well understood, and therapies to augment HSC DNA repair following myelosuppres...

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Vydáno v:Blood
Hlavní autoři: Fang, Tiancheng, Zhang, Yurun, Chang, Vivian Y., Roos, Martina, Termini, Christina M., Signaevskaia, Lia, Quarmyne, Mamle, Lin, Paulina K., Pang, Amara, Kan, Jenny, Yan, Xiao, Javier, Anna, Pohl, Katherine, Zhao, Liman, Scott, Peter, Himburg, Heather A., Chute, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378456/
https://ncbi.nlm.nih.gov/pubmed/32369572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005895
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