Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant transformation over time. Extrinsic regulation of HSC DNA repair is not well understood, and therapies to augment HSC DNA repair following myelosuppres...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Fang, Tiancheng, Zhang, Yurun, Chang, Vivian Y., Roos, Martina, Termini, Christina M., Signaevskaia, Lia, Quarmyne, Mamle, Lin, Paulina K., Pang, Amara, Kan, Jenny, Yan, Xiao, Javier, Anna, Pohl, Katherine, Zhao, Liman, Scott, Peter, Himburg, Heather A., Chute, John P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2020
Pynciau:
Hematopoiesis and Stem Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378456/
https://ncbi.nlm.nih.gov/pubmed/32369572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005895
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