Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known as Sp7 transcription factor 7)-expressing cells in mice promotes HS...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Himburg, Heather A, Doan, Phuong L, Quarmyne, Mamle, Yan, Xiao, Sasine, Joshua, Zhao, Liman, Hancock, Grace V, Kan, Jenny, Pohl, Katherine A., Tran, Evelyn, Chao, Nelson J, Harris, Jeffrey R, Chute, John P
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592969/
https://ncbi.nlm.nih.gov/pubmed/27918563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4251
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