Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known as Sp7 transcription factor 7)-expressing cells in mice promotes HS...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Med
Prif Awduron: Himburg, Heather A, Doan, Phuong L, Quarmyne, Mamle, Yan, Xiao, Sasine, Joshua, Zhao, Liman, Hancock, Grace V, Kan, Jenny, Pohl, Katherine A., Tran, Evelyn, Chao, Nelson J, Harris, Jeffrey R, Chute, John P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592969/
https://ncbi.nlm.nih.gov/pubmed/27918563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4251
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