PTPσ inhibitors promote hematopoietic stem cell regeneration

Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecule inhibitors of PTPσ that promote HSC regeneration...

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Publicat a:Nat Commun
Autors principals: Zhang, Yurun, Roos, Martina, Himburg, Heather, Termini, Christina M., Quarmyne, Mamle, Li, Michelle, Zhao, Liman, Kan, Jenny, Fang, Tiancheng, Yan, Xiao, Pohl, Katherine, Diers, Emelyne, Jin Gim, Hyo, Damoiseaux, Robert, Whitelegge, Julian, McBride, William, Jung, Michael E., Chute, John P.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694155/
https://ncbi.nlm.nih.gov/pubmed/31413255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11490-5
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