Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawle...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Christou, Helen, Hudalla, Hannes, Michael, Zoe, Filatava, Evgenia J., Li, Jun, Zhu, Minglin, Possomato-Vieira, Jose S., Dias-Junior, Carlos, Kourembanas, Stella, Khalil, Raouf A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774216/
https://ncbi.nlm.nih.gov/pubmed/29212831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244798
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