Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats

Pulmonary hypertension (PH) is a life-threatening disease with unclear vascular mechanisms. We tested whether PH involves abnormal pulmonary vasoconstriction and impaired vasodilation. Male Sprague-Dawley rats were exposed to hypoxia (9% O(2)) for 2 weeks or injected with single dose of monocrotalin...

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Main Authors: Mam, Virak, Tanbe, Alain F., Vitali, Sally H., Arons, Elena, Christou, Helen A., Khalil, Raouf A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2010
Ábhair:
Cardiovascular
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812110/
https://ncbi.nlm.nih.gov/pubmed/19915069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160119
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