Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawle...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Christou, Helen, Hudalla, Hannes, Michael, Zoe, Filatava, Evgenia J., Li, Jun, Zhu, Minglin, Possomato-Vieira, Jose S., Dias-Junior, Carlos, Kourembanas, Stella, Khalil, Raouf A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774216/
https://ncbi.nlm.nih.gov/pubmed/29212831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244798
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados