Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawle...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Pharmacol Exp Ther
Main Authors: Christou, Helen, Hudalla, Hannes, Michael, Zoe, Filatava, Evgenia J., Li, Jun, Zhu, Minglin, Possomato-Vieira, Jose S., Dias-Junior, Carlos, Kourembanas, Stella, Khalil, Raouf A.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
Teme:
Cardiovascular
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774216/
https://ncbi.nlm.nih.gov/pubmed/29212831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244798
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