Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide–Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model

Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawle...

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Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Christou, Helen, Hudalla, Hannes, Michael, Zoe, Filatava, Evgenia J., Li, Jun, Zhu, Minglin, Possomato-Vieira, Jose S., Dias-Junior, Carlos, Kourembanas, Stella, Khalil, Raouf A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774216/
https://ncbi.nlm.nih.gov/pubmed/29212831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.244798
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