LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b

Gating of the mammalian inward rectifier Kir1.1 at the helix bundle crossing (HBC) by intracellular pH is believed to be mediated by conformational changes in the C-terminal domain (CTD). However, the exact motion of the CTD during Kir gating remains controversial. Crystal structures and single-mole...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Nanazashvili, Mikheil, Sánchez-Rodríguez, Jorge E., Fosque, Ben, Bezanilla, Francisco, Sackin, Henry
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2018
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773755/
https://ncbi.nlm.nih.gov/pubmed/29320699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.044
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