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Residues at the Outer Mouth of Kir1.1 Determine K-Dependent Gating
Three residues (E132, F127, and R128) at the outer mouth of Kir1.1b directly affected inward rectifier gating by external K, independent of pH gating. Each of the individual mutations E132Q, F127V, F127D, and R128Y changed the normal K dependence of macroscopic conductance from hyperbolic (Km = 6 ±...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3379619/ https://ncbi.nlm.nih.gov/pubmed/22735524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.05.018 |
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