Residues at the Outer Mouth of Kir1.1 Determine K-Dependent Gating

Three residues (E132, F127, and R128) at the outer mouth of Kir1.1b directly affected inward rectifier gating by external K, independent of pH gating. Each of the individual mutations E132Q, F127V, F127D, and R128Y changed the normal K dependence of macroscopic conductance from hyperbolic (Km = 6 ±...

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Main Authors: Sackin, Henry, Nanazashvili, Mikheil, Li, Hui, Palmer, Lawrence G., Yang, Lei
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2012
Assuntos:
Channels and Transporters
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379619/
https://ncbi.nlm.nih.gov/pubmed/22735524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.05.018
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