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An Intersubunit Salt Bridge near the Selectivity Filter Stabilizes the Active State of Kir1.1
ROMK (Kir1.1) potassium channels are closed by internal acidification with a pKa of 6.7 ± 0.01 in 100 mM external K and a pKa of 7.0 ± 0.01 in 1 mM external K. Internal acidification in 1 mM K (but not 100 mM K) not only closed the pH gate but also inactivated Kir1.1, such that realkalization did no...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2726312/ https://ncbi.nlm.nih.gov/pubmed/19686653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.05.056 |
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