Modulation of Kir1.1 Inactivation by Extracellular Ca and Mg

Kir1.1 inactivation, associated with transient internal acidification, is strongly dependent on external K, Ca, and Mg. Here, we show that in 1 mM K, a 15 min internal acidification (pH 6.3) followed by a 30 min recovery (pH 8.0) produced 84 ± 3% inactivation in 2 mM Ca but only 18 ± 4% inactivation...

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Bibliografske podrobnosti
Main Authors: Sackin, Henry, Nanazashvili, Mikheil, Li, Hui, Palmer, Lawrence G., Yang, Lei
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2011
Teme:
Channels and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043228/
https://ncbi.nlm.nih.gov/pubmed/21354393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.032
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