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Dynamic Structural Differences between Human and Mouse STING Lead to Differing Sensitivity to DMXAA
The stimulator-of-interferon-genes (STING) protein is involved in innate immunity. It has recently been shown that modulation of STING can lead to an aggressive antitumor response. DMXAA is an antitumor agent that had shown great promise in murine models but failed in human clinical trials. The mole...
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| Publicado no: | Biophys J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773749/ https://ncbi.nlm.nih.gov/pubmed/29320694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.027 |
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