Mouse, but not human STING, binds and signals in response to the vascular disrupting agent DMXAA

Vascular disrupting agents (VDAs) such as DMXAA (5,6-dimethylxanthenone-4-acetic acid) represent a novel approach for cancer treatment. DMXAA has potent anti-tumor activity in mice and, despite significant pre-clinical promise, failed human clinical trials. The anti-tumor activity of DMXAA has been...

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Bibliographic Details
Main Authors: Conlon, Joseph, Burdette, Dara L., Sharma, Shruti, Bhat, Numana, Thompson, Mikayla, Jiang, Zhaozhao, Rathinam, Vijay A. K., Monks, Brian, Jin, Tengchuan, Xiao, T. Sam, Vogel, Stefanie N., Vance, Russell E., Fitzgerald, Katherine A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647383/
https://ncbi.nlm.nih.gov/pubmed/23585680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300097
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