5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential

The chemotherapeutic agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a potent inducer of type I IFNs and other cytokines. This ability is essential for its chemotherapeutic benefit in a mouse cancer model and suggests that it might also be useful as an antiviral agent. However, the mechanism u...

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Detalhes bibliográficos
Main Authors: Prantner, Daniel, Perkins, Darren J., Lai, Wendy, Williams, Mark S., Sharma, Shruti, Fitzgerald, Katherine A., Vogel, Stefanie N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501038/
https://ncbi.nlm.nih.gov/pubmed/23027866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382986
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