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The STING agonist 5,6 dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease.
Herpes simplex virus (HSV)-1 is the most common cause of sporadic viral encephalitis and accounts for 5–10% of cases worldwide. A key factor in host control of viral infection is the initiation of the interferon (IFN) response, mediated in part by the stimulator of interferon genes (STING) pathway....
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| Pubblicato in: | Virology |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6382592/ https://ncbi.nlm.nih.gov/pubmed/30648635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.01.006 |
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