Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA

The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an adaptor protein in the cyclic dinucleotide cGAMP-mediated sig...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Gao, Pu, Zillinger, Thomas, Wang, Weiyi, Ascano, Manuel, Dai, Peihong, Hartmann, Gunther, Tuschl, Thomas, Deng, Liang, Barchet, Winfried, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381552/
https://ncbi.nlm.nih.gov/pubmed/25199835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados