Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger triggering an interferon response. cGAMP is generated from GTP and ATP by cytoplasmic dsDNA sensor cGAMP synthase (cGAS). We combined structural, chemical, biochemical, and cellular assays to demonstrate that this second...

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Publicado no:Cell
Main Authors: Gao, Pu, Ascano, Manuel, Wu, Yang, Barchet, Winfried, Gaffney, Barbara L., Zillinger, Thomas, Serganov, Artem A., Liu, Yizhou, Jones, Roger A., Hartmann, Gunther, Tuschl, Thomas, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382009/
https://ncbi.nlm.nih.gov/pubmed/23647843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.046
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