Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger triggering an interferon response. cGAMP is generated from GTP and ATP by cytoplasmic dsDNA sensor cGAMP synthase (cGAS). We combined structural, chemical, biochemical, and cellular assays to demonstrate that this second...

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Publicado en:Cell
Autores principales: Gao, Pu, Ascano, Manuel, Wu, Yang, Barchet, Winfried, Gaffney, Barbara L., Zillinger, Thomas, Serganov, Artem A., Liu, Yizhou, Jones, Roger A., Hartmann, Gunther, Tuschl, Thomas, Patel, Dinshaw J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382009/
https://ncbi.nlm.nih.gov/pubmed/23647843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.046
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