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Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors
Allosteric modulators of G protein–coupled receptors, including opioid receptors, have been proposed as possible therapeutic agents with enhanced selectivity. BMS-986122 is a positive allosteric modulator (PAM) of the μ-opioid receptor (µ-OR). BMS-986187 is a structurally distinct PAM for the δ-opio...
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| Izdano u: | Mol Pharmacol |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767684/ https://ncbi.nlm.nih.gov/pubmed/29233847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109561 |
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