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Disruption of the Na(+) ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor
Positive allosteric modulation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represents a potential approach for the management of pain. We recently reported on positive allosteric modulators of MOPr (mu-PAMs), a class A G protein coupled receptor (GPCR). This...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280615/ https://ncbi.nlm.nih.gov/pubmed/25489080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415013111 |
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