Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in huma...

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Udgivet i:Sci Rep
Main Authors: Miranda, Cristobal L., Johnson, Lance A., de Montgolfier, Oriane, Elias, Valerie D., Ullrich, Lea S., Hay, Joshua J., Paraiso, Ines L., Choi, Jaewoo, Reed, Ralph L., Revel, Johana S., Kioussi, Chrissa, Bobe, Gerd, Iwaniec, Urszula T., Turner, Russell T., Katzenellenbogen, Benita S., Katzenellenbogen, John A., Blakemore, Paul R., Gombart, Adrian F., Maier, Claudia S., Raber, Jacob, Stevens, Jan F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766630/
https://ncbi.nlm.nih.gov/pubmed/29330372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18992-6
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