Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN and TXN on lipid accumulation in the liver. Non-supp...

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Veröffentlicht in:eLife
Hauptverfasser: Zhang, Yang, Bobe, Gerd, Miranda, Cristobal L, Lowry, Malcolm B, Hsu, Victor L, Lohr, Christiane V, Wong, Carmen P, Jump, Donald B, Robinson, Matthew M, Sharpton, Thomas J, Maier, Claudia S, Stevens, Jan F, Gombart, Adrian F
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205491/
https://ncbi.nlm.nih.gov/pubmed/34128467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66398
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