Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in huma...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Miranda, Cristobal L., Johnson, Lance A., de Montgolfier, Oriane, Elias, Valerie D., Ullrich, Lea S., Hay, Joshua J., Paraiso, Ines L., Choi, Jaewoo, Reed, Ralph L., Revel, Johana S., Kioussi, Chrissa, Bobe, Gerd, Iwaniec, Urszula T., Turner, Russell T., Katzenellenbogen, Benita S., Katzenellenbogen, John A., Blakemore, Paul R., Gombart, Adrian F., Maier, Claudia S., Raber, Jacob, Stevens, Jan F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766630/
https://ncbi.nlm.nih.gov/pubmed/29330372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18992-6
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