House Dust Mite–Induced Allergic Airway Disease Is Independent of IgE and FcεRIα

IgE contributes to disease exacerbations but not to baseline airway hyperresponsiveness (AHR) in human asthma. In rodent allergic airway disease (AAD), mast cell and IgE dependence for the induction of AHR has only been observed when mice are immunized with a relatively weak allergen without adjuvan...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: McKnight, Christopher G., Jude, Joseph A., Zhu, Zhenqi, Panettieri, Reynold A., Finkelman, Fred D.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765415/
https://ncbi.nlm.nih.gov/pubmed/28700253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0356OC
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