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Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors

N,C-capped dipeptides belong to a class of noncovalent proteasome inhibitors. Here we report that insertion of a β-amino acid in N,C-capped dipeptides markedly reduces the inhibitory potency against human constitutive proteasome, yet maintains potent inhibitory activity against human immunoproteasom...

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Bibliografiske detaljer
Udgivet i:ChemMedChem
Main Authors: Singh, Pradeep K, Fan, Hao, Jiang, Xiuju, Shi, Lei, Nathan, Carl F, Lin, Gang
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760267/
https://ncbi.nlm.nih.gov/pubmed/27561172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600384
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