Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subuni...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Santos, Ruda de Luna Almeida, Bai, Lin, Singh, Pradeep K., Murakami, Naoka, Fan, Hao, Zhan, Wenhu, Zhu, Yingrong, Jiang, Xiuju, Zhang, Kaiming, Assker, Jean Pierre, Nathan, Carl F., Li, Huilin, Azzi, Jamil, Lin, Gang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700161/
https://ncbi.nlm.nih.gov/pubmed/29167449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01760-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker