Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subuni...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Santos, Ruda de Luna Almeida, Bai, Lin, Singh, Pradeep K., Murakami, Naoka, Fan, Hao, Zhan, Wenhu, Zhu, Yingrong, Jiang, Xiuju, Zhang, Kaiming, Assker, Jean Pierre, Nathan, Carl F., Li, Huilin, Azzi, Jamil, Lin, Gang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700161/
https://ncbi.nlm.nih.gov/pubmed/29167449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01760-5
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