Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subuni...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Santos, Ruda de Luna Almeida, Bai, Lin, Singh, Pradeep K., Murakami, Naoka, Fan, Hao, Zhan, Wenhu, Zhu, Yingrong, Jiang, Xiuju, Zhang, Kaiming, Assker, Jean Pierre, Nathan, Carl F., Li, Huilin, Azzi, Jamil, Lin, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700161/
https://ncbi.nlm.nih.gov/pubmed/29167449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01760-5
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