Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome, the immunoproteasome (i-20S), is highly expressed in human T cells, dendritic cells (DCs), and B cells, suggesting that it cou...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sula Karreci, Esilida, Fan, Hao, Uehara, Mayuko, Mihali, Albana B., Singh, Pradeep K., Kurdi, Ahmed T., Solhjou, Zhabiz, Riella, Leonardo V., Ghobrial, Irene, Laragione, Teresina, Routray, Sujit, Assaker, Jean Pierre, Wang, Rong, Sukenick, George, Shi, Lei, Barrat, Franck J., Nathan, Carl F., Lin, Gang, Azzi, Jamil
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206568/
https://ncbi.nlm.nih.gov/pubmed/27956634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618548114
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