Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation

Tregs hold great promise as a cellular therapy for multiple immunologically mediated diseases, given their ability to control immune responses. The success of such strategies depends on the expansion of healthy, suppressive Tregs ex vivo and in vivo following the transfer. In clinical studies, level...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sula Karreci, Esilida, Eskandari, Siawosh K., Dotiwala, Farokh, Routray, Sujit K., Kurdi, Ahmed T., Assaker, Jean Pierre, Luckyanchykov, Pavlo, Mihali, Albana B., Maarouf, Omar, Borges, Thiago J., Alkhudhayri, Abdullah, Patel, Kruti R., Radwan, Amr, Ghobrial, Irene, McGrath, Martina, Chandraker, Anil, Riella, Leonardo V., Elyaman, Wassim, Abdi, Reza, Lieberman, Judy, Azzi, Jamil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690280/
https://ncbi.nlm.nih.gov/pubmed/29093262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91599
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