Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

Protozoan infections are a serious global health problem(1,2). Natural killer (NK) cells and cytolytic T lymphocytes (CTLs) eliminate pathogen-infected cells by releasing cytolytic granule contents—granzyme (Gzm) proteases and the pore-forming perforin (PFN)—into the infected cell(3). However, these...

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Bibliographic Details
Published in:Nat Med
Main Authors: Dotiwala, Farokh, Mulik, Sachin, Polidoro, Rafael B, Ansara, James A, Burleigh, Barbara A, Walch, Michael, Gazzinelli, Ricardo T, Lieberman, Judy
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325279/
https://ncbi.nlm.nih.gov/pubmed/26752517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4023
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