Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts

Maternal decidual NK cells (dNK) promote placentation, but how they protect against placental infection, while maintaining fetal tolerance, is unclear. Here we show human dNK highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophobl...

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Gepubliceerd in:Cell
Hoofdauteurs: Crespo, Ângela C., Mulik, Sachin, Dotiwala, Farokh, Ansara, James A., Santara, Sumit Sen, Ingersoll, Kayleigh, Ovies, Cristian, Junqueira, Caroline, Tilburgs, Tamara, Strominger, Jack L., Lieberman, Judy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484179/
https://ncbi.nlm.nih.gov/pubmed/32822574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.07.019
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