Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts

Maternal decidual NK cells (dNK) promote placentation, but how they protect against placental infection, while maintaining fetal tolerance, is unclear. Here we show human dNK highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophobl...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Crespo, Ângela C., Mulik, Sachin, Dotiwala, Farokh, Ansara, James A., Santara, Sumit Sen, Ingersoll, Kayleigh, Ovies, Cristian, Junqueira, Caroline, Tilburgs, Tamara, Strominger, Jack L., Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484179/
https://ncbi.nlm.nih.gov/pubmed/32822574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.07.019
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