Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation

Tregs hold great promise as a cellular therapy for multiple immunologically mediated diseases, given their ability to control immune responses. The success of such strategies depends on the expansion of healthy, suppressive Tregs ex vivo and in vivo following the transfer. In clinical studies, level...

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Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Sula Karreci, Esilida, Eskandari, Siawosh K., Dotiwala, Farokh, Routray, Sujit K., Kurdi, Ahmed T., Assaker, Jean Pierre, Luckyanchykov, Pavlo, Mihali, Albana B., Maarouf, Omar, Borges, Thiago J., Alkhudhayri, Abdullah, Patel, Kruti R., Radwan, Amr, Ghobrial, Irene, McGrath, Martina, Chandraker, Anil, Riella, Leonardo V., Elyaman, Wassim, Abdi, Reza, Lieberman, Judy, Azzi, Jamil
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690280/
https://ncbi.nlm.nih.gov/pubmed/29093262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91599
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