Structure-activity relationships of noncovalent immunoproteasome β5i-selective dipeptides

The immunoproteasome (i-20S) has emerged as a therapeutic target for autoimmune and inflammatory disorders and hematological malignancies. Inhibition of the chymotryptic β5i subunit of i-20S inhibits T cell activation, B cell proliferation and dendritic cell differentiation in vitro and suppresses i...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zhan, Wenhu, Singh, Pradeep K, Ban, Yi, Qing, Xiaoping, Ah Kioon, Marie Dominique, Fan, Hao, Zhao, Quanju, Wang, Rong, Sukenick, George, Salmon, Jane, Warren, J David, Ma, Xiaojing, Barrat, Franck J., Nathan, Carl F., Lin, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086754/
https://ncbi.nlm.nih.gov/pubmed/33095579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01520
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