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Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T cell activation. The effects of PI3Kγ and PI3Kδ on alloimmunity remain underexplored. Here, we show that both PI3Kγ (−/−) and PI3Kδ (D910A/D910...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5643371/ https://ncbi.nlm.nih.gov/pubmed/29038423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00982-x |
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