Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T cell activation. The effects of PI3Kγ and PI3Kδ on alloimmunity remain underexplored. Here, we show that both PI3Kγ (−/−) and PI3Kδ (D910A/D910...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Uehara, Mayuko, McGrath, Martina M., Ohori, Shunsuke, Solhjou, Zhabiz, Banouni, Naima, Routray, Sujit, Evans, Catherine, DiNitto, Jonathan P., Elkhal, Abdallah, Turka, Laurence A., Strom, Terry B., Tullius, Stefan G., Winkler, David G., Azzi, Jamil, Abdi, Reza
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643371/
https://ncbi.nlm.nih.gov/pubmed/29038423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00982-x
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