Ischemia augments alloimmune injury through IL-6-driven CD4(+) alloreactivity

Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen specific alloimmunity. We demonstrate that ischemia promotes alloimmune activation, leadin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uehara, Mayuko, Solhjou, Zhabiz, Banouni, Naima, Kasinath, Vivek, Xiaqun, Ye, Dai, Li, Yilmam, Osman, Yilmaz, Mine, Ichimura, Takaharu, Fiorina, Paolo, Martins, Paulo N., Ohori, Shunsuke, Guleria, Indira, Maarouf, Omar H., Tullius, Stefan G., McGrath, Martina M., Abdi, Reza
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802749/
https://ncbi.nlm.nih.gov/pubmed/29410442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20858-4
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