Ischemia augments alloimmune injury through IL-6-driven CD4(+) alloreactivity

Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen specific alloimmunity. We demonstrate that ischemia promotes alloimmune activation, leadin...

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Vydáno v:Sci Rep
Hlavní autoři: Uehara, Mayuko, Solhjou, Zhabiz, Banouni, Naima, Kasinath, Vivek, Xiaqun, Ye, Dai, Li, Yilmam, Osman, Yilmaz, Mine, Ichimura, Takaharu, Fiorina, Paolo, Martins, Paulo N., Ohori, Shunsuke, Guleria, Indira, Maarouf, Omar H., Tullius, Stefan G., McGrath, Martina M., Abdi, Reza
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802749/
https://ncbi.nlm.nih.gov/pubmed/29410442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20858-4
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