Ischemia augments alloimmune injury through IL-6-driven CD4(+) alloreactivity

Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen specific alloimmunity. We demonstrate that ischemia promotes alloimmune activation, leadin...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Uehara, Mayuko, Solhjou, Zhabiz, Banouni, Naima, Kasinath, Vivek, Xiaqun, Ye, Dai, Li, Yilmam, Osman, Yilmaz, Mine, Ichimura, Takaharu, Fiorina, Paolo, Martins, Paulo N., Ohori, Shunsuke, Guleria, Indira, Maarouf, Omar H., Tullius, Stefan G., McGrath, Martina M., Abdi, Reza
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802749/
https://ncbi.nlm.nih.gov/pubmed/29410442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20858-4
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