Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy

Cardiac hypertrophy without appropriate treatment eventually progresses to heart failure. Our recent data demonstrated that the immunoproteasome subunit β5i promotes cardiac hypertrophy. However, whether β5i is a promising therapeutic target for treating hypertrophic remodeling remains unknown. Here...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Xie, Xin, Wang, Hong-Xia, Li, Nan, Deng, Ya-Wen, Bi, Hai-Lian, Zhang, Yun-Long, Xia, Yun-Long, Li, Hui-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303343/
https://ncbi.nlm.nih.gov/pubmed/32595507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00885
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