The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor

Pathological cardiac hypertrophy leads to heart failure (HF). The ubiquitin-proteasome system (UPS) plays a key role in maintaining protein homeostasis and cardiac function. However, research on the role of deubiquitinating enzymes (DUBs) in cardiac function is limited. Here, we observed that the de...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Bi, Hai-Lian, Zhang, Xiao-Li, Zhang, Yun-Long, Xie, Xin, Xia, Yun-Long, Du, Jie, Li, Hui-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164950/
https://ncbi.nlm.nih.gov/pubmed/32494592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax4826
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