mTOR drives cerebral blood flow and memory deficits in LDLR(−/−) mice modeling atherosclerosis and vascular cognitive impairment

We recently showed that mTOR attenuation blocks progression and abrogates established cognitive deficits in Alzheimer’s disease (AD) mouse models. These outcomes were associated with the restoration of cerebral blood flow (CBF) and brain vascular density (BVD) resulting from relief of mTOR inhibitio...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Jahrling, Jordan B, Lin, Ai-Ling, DeRosa, Nicholas, Hussong, Stacy A, Van Skike, Candice E, Girotti, Milena, Javors, Martin, Zhao, Qingwei, Maslin, Leigh Ann, Asmis, Reto, Galvan, Veronica
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757441/
https://ncbi.nlm.nih.gov/pubmed/28511572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17705973
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