What have novel imaging techniques revealed about metabolism in the aging brain?

Por Lin, Ai-Ling, Rothman, Douglas L
Publicado em 2014

Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice

Por Guo, Janet, Bakshi, Vikas, Lin, Ai-Ling
Publicado no Front Aging Neurosci (2015)

mTOR: Alzheimer's disease prevention for APOE4 carriers

Por Lin, Ai-Ling, Butterfield, David Allan, Richardson, Arlan
Publicado no Oncotarget (2016)

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain

Por Lin, Ai-Ling, Zhang, Wei, Gao, Xiaoli, Watts, Lora
Publicado no Neurobiol Aging (2015)

Cerebral Blood Volume Measurements – Gd_DTPA vs. VASO - and Their Relationship with Cerebral Blood Flow in Activated Human Visual Cortex

Por Lin, Ai-Ling, Lu, Hanzhang, Fox, Peter T, Duong, Timothy Q
Publicado em 2011

Blood longitudinal (T(1)) and transverse (T(2)) relaxation time constants at 11.7 Tesla

Por Lin, Ai-Ling, Qin, Qin, Zhao, Xia, Duong, Timothy Q.
Publicado em 2011

Functional Neuroimaging: A Physiological Perspective

Por Lin, Ai-Ling, Gao, Jia-Hong, Duong, Timonthy Q., Fox, Peter T.
Publicado em 2010

Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease

Por Lin, Ai-Ling, Laird, Angela R., Fox, Peter T., Gao, Jia-Hong
Publicado em 2012

Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity

Por Lin, Ai-Ling, Coman, Daniel, Jiang, Lihong, Rothman, Douglas L, Hyder, Fahmeed
Publicado em 2014

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex

Por Lin, Ai-Ling, Fox, Peter T., Hardies, Jean, Duong, Timothy Q., Gao, Jia-Hong
Publicado em 2010

Validation of VASO Cerebral Blood Volume Measurement with Positron Emission Tomography

Por Uh, Jinsoo, Lin, Ai-Ling, Lee, Kihak, Liu, Peiying, Fox, Peter, Lu, Hanzhang
Publicado em 2010

Resting-State Regional Cerebral Blood Flow During Adolescence: Associations with Initiation of Substance Use and Prediction of Future Use Disorders

Por Ramage, Amy E., Lin, Ai-Ling, Olvera, Rene L., Fox, Peter T., Williamson, Douglas E.
Publicado no Drug Alcohol Depend (2015)

Evaluation of MRI Models in the Measurement of CMRO(2) and Its Relationship With CBF

Por Lin, Ai-Ling, Fox, Peter T., Yang, Yihong, Lu, Hanzhang, Tan, Li-Hai, Gao, Jia-Hong
Publicado em 2008

Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a (13)C-NMR study

Por Sancheti, Harsh, Patil, Ishan, Kanamori, Keiko, Díaz Brinton, Roberta, Zhang, Wei, Lin, Ai-Ling, Cadenas, Enrique
Publicado no J Cereb Blood Flow Metab (2014)

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

Por Lin, Ai-Ling, Jahrling, Jordan B, Zhang, Wei, DeRosa, Nicholas, Bakshi, Vikas, Romero, Peter, Galvan, Veronica, Richardson, Arlan
Publicado no J Cereb Blood Flow Metab (2015)

Multimodal bioimaging using rare earth doped Gd(2)O(2)S: Yb/Er phosphor with upconversion luminescence and magnetic resonance properties

Por Ajithkumar, G., Yoo, Benjamin, Goral, Dara E., Hornsby, Peter J., Lin, Ai-Ling, Ladiwala, Uma, Dravid, Vinayak P., Sardar, Dhiraj K
Publicado em 2013

Complex IV Deficient Surf1(−/−) Mice Initiate Mitochondrial Stress Responses

Por Pulliam, Daniel A., Deepa, Sathyaseelan S., Liu, Yuhong, Hill, Shauna, Lin, Ai-Ling, Bhattacharya, Arunabh, Shi, Yun, Sloane, Lauren, Viscomi, Carlo, Zeviani, Massimo, Van Remmen, Holly
Publicado em 2014

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

Por Parikh, Ishita, Guo, Janet, Chuang, Kai-Hsiang, Zhong, Yu, Rempe, Ralf G., Hoffman, Jared D., Armstrong, Rachel, Bauer, Björn, Hartz, Anika M.S., Lin, Ai-Ling
Publicado no Aging (Albany NY) (2016)

Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism

Por Anderson, Katie L., Frazier, Hilaree N., Maimaiti, Shaniya, Bakshi, Vikas V., Majeed, Zana R., Brewer, Lawrence D., Porter, Nada M., Lin, Ai-Ling, Thibault, Olivier
Publicado no J Gerontol A Biol Sci Med Sci (2017)

Methylene Blue as a Cerebral Metabolic and Hemodynamic Enhancer

Por Lin, Ai-Ling, Poteet, Ethan, Du, Fang, Gourav, Roy C., Liu, Ran, Wen, Yi, Bresnen, Andrew, Huang, Shiliang, Fox, Peter T., Yang, Shao-Hua, Duong, Timothy Q.
Publicado em 2012