Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-derived factors into the brain parenchyma. The BBB is damaged in Alzheimer’s disease (AD), which contributes significantly to the progression of AD pathologies and cognitive decline. However, the mechanisms unde...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Van Skike, Candice E., Jahrling, Jordan B., Olson, Angela B., Sayre, Naomi L., Hussong, Stacy A., Ungvari, Zoltan, Lechleiter, James D., Galvan, Veronica
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966773/
https://ncbi.nlm.nih.gov/pubmed/29351469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00570.2017
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