mTOR drives cerebral blood flow and memory deficits in LDLR(−/−) mice modeling atherosclerosis and vascular cognitive impairment

We recently showed that mTOR attenuation blocks progression and abrogates established cognitive deficits in Alzheimer’s disease (AD) mouse models. These outcomes were associated with the restoration of cerebral blood flow (CBF) and brain vascular density (BVD) resulting from relief of mTOR inhibitio...

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Библиографические подробности
Опубликовано в: :J Cereb Blood Flow Metab
Главные авторы: Jahrling, Jordan B, Lin, Ai-Ling, DeRosa, Nicholas, Hussong, Stacy A, Van Skike, Candice E, Girotti, Milena, Javors, Martin, Zhao, Qingwei, Maslin, Leigh Ann, Asmis, Reto, Galvan, Veronica
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2017
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757441/
https://ncbi.nlm.nih.gov/pubmed/28511572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17705973
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