mTOR drives cerebral blood flow and memory deficits in LDLR(−/−) mice modeling atherosclerosis and vascular cognitive impairment

We recently showed that mTOR attenuation blocks progression and abrogates established cognitive deficits in Alzheimer’s disease (AD) mouse models. These outcomes were associated with the restoration of cerebral blood flow (CBF) and brain vascular density (BVD) resulting from relief of mTOR inhibitio...

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Bibliografski detalji
Izdano u:J Cereb Blood Flow Metab
Glavni autori: Jahrling, Jordan B, Lin, Ai-Ling, DeRosa, Nicholas, Hussong, Stacy A, Van Skike, Candice E, Girotti, Milena, Javors, Martin, Zhao, Qingwei, Maslin, Leigh Ann, Asmis, Reto, Galvan, Veronica
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2017
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757441/
https://ncbi.nlm.nih.gov/pubmed/28511572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17705973
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