mTOR drives cerebral blood flow and memory deficits in LDLR(−/−) mice modeling atherosclerosis and vascular cognitive impairment

We recently showed that mTOR attenuation blocks progression and abrogates established cognitive deficits in Alzheimer’s disease (AD) mouse models. These outcomes were associated with the restoration of cerebral blood flow (CBF) and brain vascular density (BVD) resulting from relief of mTOR inhibitio...

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Dades bibliogràfiques
Publicat a:J Cereb Blood Flow Metab
Autors principals: Jahrling, Jordan B, Lin, Ai-Ling, DeRosa, Nicholas, Hussong, Stacy A, Van Skike, Candice E, Girotti, Milena, Javors, Martin, Zhao, Qingwei, Maslin, Leigh Ann, Asmis, Reto, Galvan, Veronica
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757441/
https://ncbi.nlm.nih.gov/pubmed/28511572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17705973
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