mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with aging and is one of the earliest events in the pathogenesis of Alzheimer's disease (AD). We have previously shown that...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Van Skike, Candice E., Lin, Ai‐Ling, Roberts Burbank, Raquel, Halloran, Jonathan J., Hernandez, Stephen F., Cuvillier, James, Soto, Vanessa Y., Hussong, Stacy A., Jahrling, Jordan B., Javors, Martin A., Hart, Matthew J., Fischer, Kathleen E., Austad, Steven N., Galvan, Veronica
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974719/
https://ncbi.nlm.nih.gov/pubmed/31693798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13057
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