Active-site solvent replenishment observed during human carbonic anhydrase II catalysis

Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO(2)/HCO(3) (−). Although hCA II has been extensively studied to investigate the proton-transfer process that occurs in the active site, its underlying mechanism is still not fully un...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:IUCrJ
Main Authors: Kim, Jin Kyun, Lomelino, Carrie L., Avvaru, Balendu Sankara, Mahon, Brian P., McKenna, Robert, Park, SangYoun, Kim, Chae Un
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2018
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755581/
https://ncbi.nlm.nih.gov/pubmed/29354275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252517017626
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