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Active-site solvent replenishment observed during human carbonic anhydrase II catalysis
Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO(2)/HCO(3) (−). Although hCA II has been extensively studied to investigate the proton-transfer process that occurs in the active site, its underlying mechanism is still not fully un...
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| Pubblicato in: | IUCrJ |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Union of Crystallography
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5755581/ https://ncbi.nlm.nih.gov/pubmed/29354275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252517017626 |
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