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Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II ,

Catalysis by the zinc metalloenzyme human carbonic anhydrase II (HCA II) is limited in maximal velocity by proton transfer between His64 and the zinc-bound solvent molecule. Asn62 extends into the active site cavity of HCA II adjacent to His64 and has been shown to be one of several hydrophilic resi...

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Main Authors: Zheng, Jiayin, Avvaru, Balendu Sankara, Tu, Chingkuang, McKenna, Robert, Silverman, David N.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702124/
https://ncbi.nlm.nih.gov/pubmed/18942852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801473w
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