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Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II ,
Catalysis by the zinc metalloenzyme human carbonic anhydrase II (HCA II) is limited in maximal velocity by proton transfer between His64 and the zinc-bound solvent molecule. Asn62 extends into the active site cavity of HCA II adjacent to His64 and has been shown to be one of several hydrophilic resi...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2702124/ https://ncbi.nlm.nih.gov/pubmed/18942852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801473w |
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