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Kinetic and Crystallographic Studies of the Role of Tyrosine 7 in the Active Site of Human Carbonic Anhydrase II
The rate limiting step in catalysis of bicarbonate dehydration by human carbonic anhydrase II (HCA II) is an intramolecular proton transfer from His64 to the zinc-bound hydroxide. We have examined the role of Tyr7 using site-specific mutagenesis and measuring catalysis by the (18)O exchange method u...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044917/ https://ncbi.nlm.nih.gov/pubmed/21145876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.004 |
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