Kinetic and Crystallographic Studies of the Role of Tyrosine 7 in the Active Site of Human Carbonic Anhydrase II

The rate limiting step in catalysis of bicarbonate dehydration by human carbonic anhydrase II (HCA II) is an intramolecular proton transfer from His64 to the zinc-bound hydroxide. We have examined the role of Tyr7 using site-specific mutagenesis and measuring catalysis by the (18)O exchange method u...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Mikulski, Rose, Avvaru, Balendu Sankara, Tu, Chingkuang, Case, Nicolette, McKenna, Robert, Silverman, David N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044917/
https://ncbi.nlm.nih.gov/pubmed/21145876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.004
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items