Caricamento...

Kinetic and Crystallographic Studies of the Role of Tyrosine 7 in the Active Site of Human Carbonic Anhydrase II

The rate limiting step in catalysis of bicarbonate dehydration by human carbonic anhydrase II (HCA II) is an intramolecular proton transfer from His64 to the zinc-bound hydroxide. We have examined the role of Tyr7 using site-specific mutagenesis and measuring catalysis by the (18)O exchange method u...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Mikulski, Rose, Avvaru, Balendu Sankara, Tu, Chingkuang, Case, Nicolette, McKenna, Robert, Silverman, David N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044917/
https://ncbi.nlm.nih.gov/pubmed/21145876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.004
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !