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Kinetic and Crystallographic Studies of the Role of Tyrosine 7 in the Active Site of Human Carbonic Anhydrase II

The rate limiting step in catalysis of bicarbonate dehydration by human carbonic anhydrase II (HCA II) is an intramolecular proton transfer from His64 to the zinc-bound hydroxide. We have examined the role of Tyr7 using site-specific mutagenesis and measuring catalysis by the (18)O exchange method u...

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Bibliografiske detaljer
Main Authors: Mikulski, Rose, Avvaru, Balendu Sankara, Tu, Chingkuang, Case, Nicolette, McKenna, Robert, Silverman, David N.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044917/
https://ncbi.nlm.nih.gov/pubmed/21145876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.004
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