Design of a Carbonic Anhydrase IX Active-Site Mimic to Screen Inhibitors for Possible Anti-Cancer Properties,

Recently a convincing body of evidence has accumulated, suggesting that the over-expression of carbonic anhydrase isozyme IX (CA IX) in some cancers contributes to the acidification of the extracellular matrix, which in turn promotes the growth and metastasis of the tumor. These observations have ma...

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Detalhes bibliográficos
Main Authors: Genis, Caroli, Sippel, Katherine H., Case, Nicolette, Cao, Wengang, Avvaru, Balendu Sankara, Tartaglia, Lawrence J., Govindasamy, Lakshmanan, Tu, Chingkuang, Agbandje-McKenna, Mavis, Silverman, David N., Rosser, Charles J., McKenna, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713499/
https://ncbi.nlm.nih.gov/pubmed/19170619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802035f
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